Molecular predictive markers in tumors of the gastrointestinal tract

Gastrointestinal malignancies are among the leading causes of cancer-related deaths worldwide. Like all human malignancies they are characterized by accumulation of mutations which lead to inactivation of tumor suppressor genes or activation of oncogenes. Advances in Molecular Biology techniques hav...

Full description

Bibliographic Details
Main Authors:	Papadopoulou, Eirini, Metaxa-Mariatou, Vasiliki, Tsaousis, Georgios, Tsoulos, Nikolaos, Tsirigoti, Angeliki, Efstathiadou, Chrisoula, Apessos, Angela, Agiannitopoulos, Konstantinos, Pepe, Georgia, Bourkoula, Eugenia, Nasioulas, George
Format:	Online
Language:	English
Published:	Baishideng Publishing Group Inc 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108979/

id	pubmed-5108979
recordtype	oai_dc
spelling	pubmed-51089792016-11-28 Molecular predictive markers in tumors of the gastrointestinal tract Papadopoulou, Eirini Metaxa-Mariatou, Vasiliki Tsaousis, Georgios Tsoulos, Nikolaos Tsirigoti, Angeliki Efstathiadou, Chrisoula Apessos, Angela Agiannitopoulos, Konstantinos Pepe, Georgia Bourkoula, Eugenia Nasioulas, George Review Gastrointestinal malignancies are among the leading causes of cancer-related deaths worldwide. Like all human malignancies they are characterized by accumulation of mutations which lead to inactivation of tumor suppressor genes or activation of oncogenes. Advances in Molecular Biology techniques have allowed for more accurate analysis of tumors’ genetic profiling using new breakthrough technologies such as next generation sequencing (NGS), leading to the development of targeted therapeutical approaches based upon biomarker-selection. During the last 10 years tremendous advances in the development of targeted therapies for patients with advanced cancer have been made, thus various targeted agents, associated with predictive biomarkers, have been developed or are in development for the treatment of patients with gastrointestinal cancer patients. This review summarizes the advances in the field of molecular biomarkers in tumors of the gastrointestinal tract, with focus on the available NGS platforms that enable comprehensive tumor molecular profile analysis. Baishideng Publishing Group Inc 2016-11-15 2016-11-15 /pmc/articles/PMC5108979/ /pubmed/27895815 http://dx.doi.org/10.4251/wjgo.v8.i11.772 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Papadopoulou, Eirini Metaxa-Mariatou, Vasiliki Tsaousis, Georgios Tsoulos, Nikolaos Tsirigoti, Angeliki Efstathiadou, Chrisoula Apessos, Angela Agiannitopoulos, Konstantinos Pepe, Georgia Bourkoula, Eugenia Nasioulas, George
spellingShingle	Papadopoulou, Eirini Metaxa-Mariatou, Vasiliki Tsaousis, Georgios Tsoulos, Nikolaos Tsirigoti, Angeliki Efstathiadou, Chrisoula Apessos, Angela Agiannitopoulos, Konstantinos Pepe, Georgia Bourkoula, Eugenia Nasioulas, George Molecular predictive markers in tumors of the gastrointestinal tract
author_facet	Papadopoulou, Eirini Metaxa-Mariatou, Vasiliki Tsaousis, Georgios Tsoulos, Nikolaos Tsirigoti, Angeliki Efstathiadou, Chrisoula Apessos, Angela Agiannitopoulos, Konstantinos Pepe, Georgia Bourkoula, Eugenia Nasioulas, George
author_sort	Papadopoulou, Eirini
title	Molecular predictive markers in tumors of the gastrointestinal tract
title_short	Molecular predictive markers in tumors of the gastrointestinal tract
title_full	Molecular predictive markers in tumors of the gastrointestinal tract
title_fullStr	Molecular predictive markers in tumors of the gastrointestinal tract
title_full_unstemmed	Molecular predictive markers in tumors of the gastrointestinal tract
title_sort	molecular predictive markers in tumors of the gastrointestinal tract
description	Gastrointestinal malignancies are among the leading causes of cancer-related deaths worldwide. Like all human malignancies they are characterized by accumulation of mutations which lead to inactivation of tumor suppressor genes or activation of oncogenes. Advances in Molecular Biology techniques have allowed for more accurate analysis of tumors’ genetic profiling using new breakthrough technologies such as next generation sequencing (NGS), leading to the development of targeted therapeutical approaches based upon biomarker-selection. During the last 10 years tremendous advances in the development of targeted therapies for patients with advanced cancer have been made, thus various targeted agents, associated with predictive biomarkers, have been developed or are in development for the treatment of patients with gastrointestinal cancer patients. This review summarizes the advances in the field of molecular biomarkers in tumors of the gastrointestinal tract, with focus on the available NGS platforms that enable comprehensive tumor molecular profile analysis.
publisher	Baishideng Publishing Group Inc
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108979/
_version_	1613726634465034240

Molecular predictive markers in tumors of the gastrointestinal tract

Similar Items