Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation

Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation

Type 2 diabetes is a chronic metabolic disorder, where failure to maintain normal glucose homoeostasis is associated with, and exacerbated by, obesity and the concomitant-elevated free fatty acid concentrations typically found in these patients. Hyperglycaemia and hyperlipidaemia together contribute...

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Bibliographic Details
Main Authors: Bagnati, Marta, Ogunkolade, Babatunji W, Marshall, Catriona, Tucci, Carmen, Hanna, Katie, Jones, Tania A, Bugliani, Marco, Nedjai, Belinda, Caton, Paul W, Kieswich, Julius, Yaqoob, Muhammed M, Ball, Graham R, Marchetti, Piero, Hitman, Graham A, Turner, Mark D
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108311/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108311/

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