Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs

Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs

Mammalian cells are an indispensable tool for the production of recombinant proteins in contexts where function depends on post-translational modifications. Among them, Chinese Hamster Ovary (CHO) cells are the primary factories for the production of therapeutic proteins, including monoclonal antibo...

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Bibliographic Details
Main Authors: Zucchelli, Silvia, Patrucco, Laura, Persichetti, Francesca, Gustincich, Stefano, Cotella, Diego
Format: Online
Language:English
Published: Research Network of Computational and Structural Biotechnology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107644/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107644/

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