Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes

Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes

Our hypothesis is that allosteric receptor-receptor interactions in homo- and heteroreceptor complexes may form the molecular basis of learning and memory. This principle is illustrated by showing how cocaine abuse can alter the adenosine A2AR-dopamine D2R heterocomplexes and their receptor-receptor...

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Bibliographic Details
Main Authors: Borroto-Escuela, Dasiel O., Wydra, Karolina, Pintsuk, Julia, Narvaez, Manuel, Corrales, Fidel, Zaniewska, Magdalena, Agnati, Luigi F., Franco, Rafael, Tanganelli, Sergio, Ferraro, Luca, Filip, Malgorzata, Fuxe, Kjell
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107220/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107220/

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