Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China

Influenza A virus (IAV) subtypes against which little or no pre-existing immunity exists in humans represent a serious threat to global public health. Monitoring of IAV in animal hosts is essential for early and rapid detection of potential pandemic IAV strains to prevent their spread. Recently, the...

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Main Authors:	Veljkovic, Veljko, Veljkovic, Nevena, Paessler, Slobodan, Goeijenbier, Marco, Perovic, Vladimir, Glisic, Sanja, Muller, Claude P.
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102363/

id	pubmed-5102363
recordtype	oai_dc
spelling	pubmed-51023632016-11-18 Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China Veljkovic, Veljko Veljkovic, Nevena Paessler, Slobodan Goeijenbier, Marco Perovic, Vladimir Glisic, Sanja Muller, Claude P. Research Article Influenza A virus (IAV) subtypes against which little or no pre-existing immunity exists in humans represent a serious threat to global public health. Monitoring of IAV in animal hosts is essential for early and rapid detection of potential pandemic IAV strains to prevent their spread. Recently, the increased pandemic potential of the avian-like swine H1N1 IAV A/swine/Guangdong/104/2013 has been suggested. The virus is infectious in humans and the general population seems to lack neutralizing antibodies against this virus. Here we present an in silico analysis that shows a strong human propensity of this swine virus further confirming its pandemic potential. We suggest mutations which would further enhance its human propensity. We also propose conserved antigenic determinants which could serve as a component of a prepandemic vaccine. The bioinformatics tool, which can be used to further monitor the evolution of swine influenza viruses towards a pandemic virus, are described here and are made publically available (http://www.vin.bg.ac.rs/180/tools/iav_mon.php; http://www.biomedprotection.com/iav_mon.php). Public Library of Science 2016-11-09 /pmc/articles/PMC5102363/ /pubmed/27828989 http://dx.doi.org/10.1371/journal.pone.0165451 Text en © 2016 Veljkovic et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Veljkovic, Veljko Veljkovic, Nevena Paessler, Slobodan Goeijenbier, Marco Perovic, Vladimir Glisic, Sanja Muller, Claude P.
spellingShingle	Veljkovic, Veljko Veljkovic, Nevena Paessler, Slobodan Goeijenbier, Marco Perovic, Vladimir Glisic, Sanja Muller, Claude P. Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China
author_facet	Veljkovic, Veljko Veljkovic, Nevena Paessler, Slobodan Goeijenbier, Marco Perovic, Vladimir Glisic, Sanja Muller, Claude P.
author_sort	Veljkovic, Veljko
title	Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China
title_short	Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China
title_full	Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China
title_fullStr	Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China
title_full_unstemmed	Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China
title_sort	predicted enhanced human propensity of current avian-like h1n1 swine influenza virus from china
description	Influenza A virus (IAV) subtypes against which little or no pre-existing immunity exists in humans represent a serious threat to global public health. Monitoring of IAV in animal hosts is essential for early and rapid detection of potential pandemic IAV strains to prevent their spread. Recently, the increased pandemic potential of the avian-like swine H1N1 IAV A/swine/Guangdong/104/2013 has been suggested. The virus is infectious in humans and the general population seems to lack neutralizing antibodies against this virus. Here we present an in silico analysis that shows a strong human propensity of this swine virus further confirming its pandemic potential. We suggest mutations which would further enhance its human propensity. We also propose conserved antigenic determinants which could serve as a component of a prepandemic vaccine. The bioinformatics tool, which can be used to further monitor the evolution of swine influenza viruses towards a pandemic virus, are described here and are made publically available (http://www.vin.bg.ac.rs/180/tools/iav_mon.php; http://www.biomedprotection.com/iav_mon.php).
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102363/
_version_	1613719906802466816

Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China

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