Selecting instruments for Mendelian randomization in the wake of genome-wide association studies

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies

Mendelian randomization (MR) studies typically assess the pathogenic relevance of environmental exposures or disease biomarkers, using genetic variants that instrument these exposures. The approach is gaining popularity—our systematic review reveals a greater than 10-fold increase in MR studies publ...

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Bibliographic Details
Main Authors: Swerdlow, Daniel I, Kuchenbaecker, Karoline B, Shah, Sonia, Sofat, Reecha, Holmes, Michael V, White, Jon, Mindell, Jennifer S, Kivimaki, Mika, Brunner, Eric J, Whittaker, John C, Casas, Juan P, Hingorani, Aroon D
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100611/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100611/

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