A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults

A phenome-wide association study of a lipoprotein-associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been implicated in development of atherosclerosis; however, recent randomized trials of Lp-PLA2 inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be used...

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Bibliographic Details
Main Authors: Millwood, Iona Y, Bennett, Derrick A, Walters, Robin G, Clarke, Robert, Waterworth, Dawn, Johnson, Toby, Chen, Yiping, Yang, Ling, Guo, Yu, Bian, Zheng, Hacker, Alex, Yeo, Astrid, Parish, Sarah, Hill, Michael R, Chissoe, Stephanie, Peto, Richard, Cardon, Lon, Collins, Rory, Li, Liming, Chen, Zhengming
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100610/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100610/

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