Detailed Analysis of Protein Topology of Extracellular Vesicles–Evidence of Unconventional Membrane Protein Orientation

Extracellular vesicles (EVs) are important mediators of intercellular communication that change the recipient cell by shuttling lipids, RNA, or protein cargo between cells. Here, we investigate the topology of the protein cargo found in EVs, as this topology can fundamentally influence the biologica...

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Bibliographic Details
Main Authors: Cvjetkovic, Aleksander, Jang, Su Chul, Konečná, Barbora, Höög, Johanna L., Sihlbom, Carina, Lässer, Cecilia, Lötvall, Jan
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099568/