T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease

•Parkinson's disease features are reflected in spatially resolved measurement of MR T2-relaxation times.•Deep brain stimulation therapy target identification can be assisted by measurement of MR T2-relaxation times.•T2r asymmetry in the subthalamic nucleus is not associated with increased clini...

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Main Authors:	Lönnfors-Weitzel, Tarja, Weitzel, Thilo, Slotboom, Johannes, Kiefer, Claus, Pollo, Claudio, Schüpbach, Michael, Oertel, Markus, Kaelin, Alain, Wiest, Roland
Format:	Online
Language:	English
Published:	Elsevier 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097958/

id	pubmed-5097958
recordtype	oai_dc
spelling	pubmed-50979582016-11-14 T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease Lönnfors-Weitzel, Tarja Weitzel, Thilo Slotboom, Johannes Kiefer, Claus Pollo, Claudio Schüpbach, Michael Oertel, Markus Kaelin, Alain Wiest, Roland Regular Article •Parkinson's disease features are reflected in spatially resolved measurement of MR T2-relaxation times.•Deep brain stimulation therapy target identification can be assisted by measurement of MR T2-relaxation times.•T2r asymmetry in the subthalamic nucleus is not associated with increased clinical symptoms, but with response to therapy.•Lower boundaries of T2r in the STN predict motor outcome in Deep brain stimulation therapy•Patient selection criteria may be improved by including parameters based on MR relaxometry. Elsevier 2016-09-29 /pmc/articles/PMC5097958/ /pubmed/27843765 http://dx.doi.org/10.1016/j.nicl.2016.09.019 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lönnfors-Weitzel, Tarja Weitzel, Thilo Slotboom, Johannes Kiefer, Claus Pollo, Claudio Schüpbach, Michael Oertel, Markus Kaelin, Alain Wiest, Roland
spellingShingle	Lönnfors-Weitzel, Tarja Weitzel, Thilo Slotboom, Johannes Kiefer, Claus Pollo, Claudio Schüpbach, Michael Oertel, Markus Kaelin, Alain Wiest, Roland T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease
author_facet	Lönnfors-Weitzel, Tarja Weitzel, Thilo Slotboom, Johannes Kiefer, Claus Pollo, Claudio Schüpbach, Michael Oertel, Markus Kaelin, Alain Wiest, Roland
author_sort	Lönnfors-Weitzel, Tarja
title	T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease
title_short	T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease
title_full	T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease
title_fullStr	T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease
title_full_unstemmed	T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease
title_sort	t2-relaxometry predicts outcome of dbs in idiopathic parkinson's disease
description	•Parkinson's disease features are reflected in spatially resolved measurement of MR T2-relaxation times.•Deep brain stimulation therapy target identification can be assisted by measurement of MR T2-relaxation times.•T2r asymmetry in the subthalamic nucleus is not associated with increased clinical symptoms, but with response to therapy.•Lower boundaries of T2r in the STN predict motor outcome in Deep brain stimulation therapy•Patient selection criteria may be improved by including parameters based on MR relaxometry.
publisher	Elsevier
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097958/
_version_	1613715442628558848

T2-relaxometry predicts outcome of DBS in idiopathic Parkinson's disease

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