Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments
Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience. Recently, we have developed a model of phase-reversal learning of the vestibulo-ocular reflex, a well-established, cerebellar-dependent task. The model, comprising both the cerebella...
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| Format: | Online |
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Nature Publishing Group
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095348/ |
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pubmed-50953482016-11-10 Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments Badura, Aleksandra Clopath, Claudia Schonewille, Martijn De Zeeuw, Chris I. Article Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience. Recently, we have developed a model of phase-reversal learning of the vestibulo-ocular reflex, a well-established, cerebellar-dependent task. The model, comprising both the cerebellar cortex and vestibular nuclei, reproduces behavioral data and accounts for the changes in neural activity during learning in wild type mice. Here, we used our model to predict Purkinje cell spiking as well as behavior before and after learning of five different lines of mutant mice with distinct cell-specific alterations of the cerebellar cortical circuitry. We tested these predictions by obtaining electrophysiological data depicting changes in neuronal spiking. We show that our data is largely consistent with the model predictions for simple spike modulation of Purkinje cells and concomitant behavioral learning in four of the mutants. In addition, our model accurately predicts a shift in simple spike activity in a mutant mouse with a brainstem specific mutation. This combination of electrophysiological and computational techniques opens a possibility of predicting behavioral impairments from neural activity. Nature Publishing Group 2016-11-02 /pmc/articles/PMC5095348/ /pubmed/27805050 http://dx.doi.org/10.1038/srep36131 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Badura, Aleksandra Clopath, Claudia Schonewille, Martijn De Zeeuw, Chris I. |
| spellingShingle |
Badura, Aleksandra Clopath, Claudia Schonewille, Martijn De Zeeuw, Chris I. Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments |
| author_facet |
Badura, Aleksandra Clopath, Claudia Schonewille, Martijn De Zeeuw, Chris I. |
| author_sort |
Badura, Aleksandra |
| title |
Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments |
| title_short |
Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments |
| title_full |
Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments |
| title_fullStr |
Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments |
| title_full_unstemmed |
Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments |
| title_sort |
modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments |
| description |
Translating neuronal activity to measurable behavioral changes has been a long-standing goal of systems neuroscience. Recently, we have developed a model of phase-reversal learning of the vestibulo-ocular reflex, a well-established, cerebellar-dependent task. The model, comprising both the cerebellar cortex and vestibular nuclei, reproduces behavioral data and accounts for the changes in neural activity during learning in wild type mice. Here, we used our model to predict Purkinje cell spiking as well as behavior before and after learning of five different lines of mutant mice with distinct cell-specific alterations of the cerebellar cortical circuitry. We tested these predictions by obtaining electrophysiological data depicting changes in neuronal spiking. We show that our data is largely consistent with the model predictions for simple spike modulation of Purkinje cells and concomitant behavioral learning in four of the mutants. In addition, our model accurately predicts a shift in simple spike activity in a mutant mouse with a brainstem specific mutation. This combination of electrophysiological and computational techniques opens a possibility of predicting behavioral impairments from neural activity. |
| publisher |
Nature Publishing Group |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095348/ |
| _version_ |
1613712925925572608 |