Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

The glutamate transporter xCT (SCL7a11, system Xc-, SXC) is an emerging key player in glutamate/cysteine/glutathione homeostasis in the brain and in cancer. xCT expression correlates with the grade of malignancy. Here, we report on the use of the U.S. Food and Drug Administration and EMA-approved xC...

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Bibliographic Details
Main Authors: Sehm, Tina, Fan, Zheng, Ghoochani, Ali, Rauh, Manfred, Engelhorn, Tobias, Minakaki, Georgia, Dörfler, Arnd, Klucken, Jochen, Buchfelder, Michael, Eyüpoglu, Ilker Y., Savaskan, Nicolai
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094980/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094980/

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