Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection

WNV is a zoonotic neurotropic flavivirus that has recently emerged globally as a significant cause of viral encephalitis. The last five years, 624 incidents of WNV infection have been reported in Greece. The risk for severe WNV disease increases among immunosuppressed individuals implying thus the c...

Full description

Bibliographic Details
Main Authors:	Sarri, Constantina A., Markantoni, Maria, Stamatis, Costas, Papa, Anna, Tsakris, Athanasios, Pervanidou, Danai, Baka, Agoritsa, Politis, Constantina, Billinis, Charalambos, Hadjichristodoulou, Christos, Mamuris, Zissis
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094746/

id	pubmed-5094746
recordtype	oai_dc
spelling	pubmed-50947462016-11-18 Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection Sarri, Constantina A. Markantoni, Maria Stamatis, Costas Papa, Anna Tsakris, Athanasios Pervanidou, Danai Baka, Agoritsa Politis, Constantina Billinis, Charalambos Hadjichristodoulou, Christos Mamuris, Zissis Research Article WNV is a zoonotic neurotropic flavivirus that has recently emerged globally as a significant cause of viral encephalitis. The last five years, 624 incidents of WNV infection have been reported in Greece. The risk for severe WNV disease increases among immunosuppressed individuals implying thus the contribution of the MHC locus to the control of WNV infection. In order to investigate a possible association of MHC class II genes, especially HLA-DPA1, HLA-DQA1, HLA-DRB1, we examined 105 WNV patients, including 68 cases with neuroinvasive disease and 37 cases with mild clinical phenotype, collected during the period from 2010 to2013, and 100 control individuals selected form the Greek population. Typing was performed for exon 2 for all three genes. DQA101:01 was considered to be "protective" against WNV infection (25.4% vs 40.1%, P = 0.004) while DQA101:02 was associated with increased susceptibility (48.0% vs 32.1%, P = 0.003). Protection against neuroinvasion was associated with the presence of DRB111:02 (4.99% vs 0.0%, P = 0.018). DRB116:02 was also absent from the control cohort (P = 0.016). Three additional population control groups were used in order to validate our results. No statistically significant association with the disease was found for HLA-DPA alleles. The results of the present study provide some evidence that MHC class II is involved in the response to WNV infection, outlining infection "susceptibility" and "CNS-high-risk" candidates. Furthermore, three new alleles were identified while the frequency of all alleles in the study was compared with worldwide data. The characterization of the MHC locus could help to estimate the risk for severe WNV cases in a country. Public Library of Science 2016-11-03 /pmc/articles/PMC5094746/ /pubmed/27812212 http://dx.doi.org/10.1371/journal.pone.0165952 Text en © 2016 Sarri et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sarri, Constantina A. Markantoni, Maria Stamatis, Costas Papa, Anna Tsakris, Athanasios Pervanidou, Danai Baka, Agoritsa Politis, Constantina Billinis, Charalambos Hadjichristodoulou, Christos Mamuris, Zissis
spellingShingle	Sarri, Constantina A. Markantoni, Maria Stamatis, Costas Papa, Anna Tsakris, Athanasios Pervanidou, Danai Baka, Agoritsa Politis, Constantina Billinis, Charalambos Hadjichristodoulou, Christos Mamuris, Zissis Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection
author_facet	Sarri, Constantina A. Markantoni, Maria Stamatis, Costas Papa, Anna Tsakris, Athanasios Pervanidou, Danai Baka, Agoritsa Politis, Constantina Billinis, Charalambos Hadjichristodoulou, Christos Mamuris, Zissis
author_sort	Sarri, Constantina A.
title	Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection
title_short	Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection
title_full	Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection
title_fullStr	Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection
title_full_unstemmed	Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection
title_sort	genetic contribution of mhc class ii genes in susceptibility to west nile virus infection
description	WNV is a zoonotic neurotropic flavivirus that has recently emerged globally as a significant cause of viral encephalitis. The last five years, 624 incidents of WNV infection have been reported in Greece. The risk for severe WNV disease increases among immunosuppressed individuals implying thus the contribution of the MHC locus to the control of WNV infection. In order to investigate a possible association of MHC class II genes, especially HLA-DPA1, HLA-DQA1, HLA-DRB1, we examined 105 WNV patients, including 68 cases with neuroinvasive disease and 37 cases with mild clinical phenotype, collected during the period from 2010 to2013, and 100 control individuals selected form the Greek population. Typing was performed for exon 2 for all three genes. DQA101:01 was considered to be "protective" against WNV infection (25.4% vs 40.1%, P = 0.004) while DQA101:02 was associated with increased susceptibility (48.0% vs 32.1%, P = 0.003). Protection against neuroinvasion was associated with the presence of DRB111:02 (4.99% vs 0.0%, P = 0.018). DRB116:02 was also absent from the control cohort (P = 0.016). Three additional population control groups were used in order to validate our results. No statistically significant association with the disease was found for HLA-DPA alleles. The results of the present study provide some evidence that MHC class II is involved in the response to WNV infection, outlining infection "susceptibility" and "CNS-high-risk" candidates. Furthermore, three new alleles were identified while the frequency of all alleles in the study was compared with worldwide data. The characterization of the MHC locus could help to estimate the risk for severe WNV cases in a country.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094746/
_version_	1613712288757317632

Genetic Contribution of MHC Class II Genes in Susceptibility to West Nile Virus Infection

Similar Items