Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays

Spiral ganglion neurons (SGNs) participate in the physiological process of hearing by relaying signals from sensory hair cells to the cochlear nucleus in the brain stem. Loss of hair cells is a major cause of sensory hearing loss. Prosthetic devices such as cochlear implants function by bypassing lo...

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Bibliographic Details
Main Authors: Hahnewald, Stefan, Roccio, Marta, Tscherter, Anne, Streit, Jürg, Ambett, Ranjeeta, Senn, Pascal
Format: Online
Language:English
Published: MyJove Corporation 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092214/
Description
Summary:Spiral ganglion neurons (SGNs) participate in the physiological process of hearing by relaying signals from sensory hair cells to the cochlear nucleus in the brain stem. Loss of hair cells is a major cause of sensory hearing loss. Prosthetic devices such as cochlear implants function by bypassing lost hair cells and directly stimulating SGNs electrically, allowing for restoration of hearing in deaf patients. The performance of these devices depends on the functionality of SGNs, the implantation procedure and on the distance between the electrodes and the auditory neurons.