Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury
As most spinal cord injuries (SCIs) are incomplete, an important target for promoting neural repair and recovery of lost motor function is to promote the connections of spared descending spinal pathways with spinal motor circuits. Among the pathways, the corticospinal tract (CST) is most associated...
| Main Author: | |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Medknow Publications & Media Pvt Ltd
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090827/ |
| id |
pubmed-5090827 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-50908272016-11-17 Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury Martin, John H. Invited Review As most spinal cord injuries (SCIs) are incomplete, an important target for promoting neural repair and recovery of lost motor function is to promote the connections of spared descending spinal pathways with spinal motor circuits. Among the pathways, the corticospinal tract (CST) is most associated with skilled voluntary functions in humans and many animals. CST loss, whether at its origin in the motor cortex or in the white matter tracts subcortically and in the spinal cord, leads to movement impairments and paralysis. To restore motor function after injury will require repair of the damaged CST. In this review, I discuss how knowledge of activity-dependent development of the CST—which establishes connectional specificity through axon pruning, axon outgrowth, and synaptic competition among CST terminals—informed a novel activity-based therapy for promoting sprouting of spared CST axons after injur in mature animals. This therapy, which comprises motor cortex electrical stimulation with and without concurrent trans-spinal direct current stimulation, leads to an increase in the gray matter axon length of spared CST axons in the rat spinal cord and, after a pyramidal tract lesion, restoration of skilled locomotor movements. I discuss how this approach is now being applied to a C4 contusion rat model. Medknow Publications & Media Pvt Ltd 2016-09 /pmc/articles/PMC5090827/ /pubmed/27857728 http://dx.doi.org/10.4103/1673-5374.191199 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Martin, John H. |
| spellingShingle |
Martin, John H. Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury |
| author_facet |
Martin, John H. |
| author_sort |
Martin, John H. |
| title |
Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury |
| title_short |
Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury |
| title_full |
Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury |
| title_fullStr |
Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury |
| title_full_unstemmed |
Harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury |
| title_sort |
harnessing neural activity to promote repair of the damaged corticospinal system after spinal cord injury |
| description |
As most spinal cord injuries (SCIs) are incomplete, an important target for promoting neural repair and recovery of lost motor function is to promote the connections of spared descending spinal pathways with spinal motor circuits. Among the pathways, the corticospinal tract (CST) is most associated with skilled voluntary functions in humans and many animals. CST loss, whether at its origin in the motor cortex or in the white matter tracts subcortically and in the spinal cord, leads to movement impairments and paralysis. To restore motor function after injury will require repair of the damaged CST. In this review, I discuss how knowledge of activity-dependent development of the CST—which establishes connectional specificity through axon pruning, axon outgrowth, and synaptic competition among CST terminals—informed a novel activity-based therapy for promoting sprouting of spared CST axons after injur in mature animals. This therapy, which comprises motor cortex electrical stimulation with and without concurrent trans-spinal direct current stimulation, leads to an increase in the gray matter axon length of spared CST axons in the rat spinal cord and, after a pyramidal tract lesion, restoration of skilled locomotor movements. I discuss how this approach is now being applied to a C4 contusion rat model. |
| publisher |
Medknow Publications & Media Pvt Ltd |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090827/ |
| _version_ |
1613708152684937216 |