An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

The sequence of events that initiates T cell signaling is dictated by the specificities and order of activation of the tyrosine kinases that signal downstream of the T cell receptor. Using a platform that combines exhaustive point-mutagenesis of peptide substrates, bacterial surface-display, cell so...

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Bibliographic Details
Main Authors: Shah, Neel H, Wang, Qi, Yan, Qingrong, Karandur, Deepti, Kadlecek, Theresa A, Fallahee, Ian R, Russ, William P, Ranganathan, Rama, Weiss, Arthur, Kuriyan, John
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089863/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089863/

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