Saccadic latency in amblyopia
We measured saccadic latencies in a large sample (total n = 459) of individuals with amblyopia or risk factors for amblyopia, e.g., strabismus or anisometropia, and normal control subjects. We presented an easily visible target randomly to the left or right, 3.5° from fixation. The interocular diffe...
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| Format: | Online |
| Language: | English |
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The Association for Research in Vision and Ophthalmology
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089444/ |
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pubmed-50894442016-11-06 Saccadic latency in amblyopia McKee, Suzanne P. Levi, Dennis M. Schor, Clifton M. Movshon, J. Anthony Article We measured saccadic latencies in a large sample (total n = 459) of individuals with amblyopia or risk factors for amblyopia, e.g., strabismus or anisometropia, and normal control subjects. We presented an easily visible target randomly to the left or right, 3.5° from fixation. The interocular difference in saccadic latency is highly correlated with the interocular difference in LogMAR (Snellen) acuity—as the acuity difference increases, so does the latency difference. Strabismic and strabismic-anisometropic amblyopes have, on average, a larger difference between their eyes in LogMAR acuity than anisometropic amblyopes and thus their interocular latency difference is, on average, significantly larger than anisometropic amblyopes. Despite its relation to LogMAR acuity, the longer latency in strabismic amblyopes cannot be attributed either to poor resolution or to reduced contrast sensitivity, because their interocular differences in grating acuity and in contrast sensitivity are roughly the same as for anisometropic amblyopes. The correlation between LogMAR acuity and saccadic latency arises because of the confluence of two separable effects in the strabismic amblyopic eye—poor letter recognition impairs LogMAR acuity while an intrinsic sluggishness delays reaction time. We speculate that the frequent microsaccades and the accompanying attentional shifts, made while strabismic amblyopes struggle to maintain fixation with their amblyopic eyes, result in all types of reactions being irreducibly delayed. The Association for Research in Vision and Ophthalmology 2016-03-10 /pmc/articles/PMC5089444/ /pubmed/26943348 http://dx.doi.org/10.1167/16.5.3 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
McKee, Suzanne P. Levi, Dennis M. Schor, Clifton M. Movshon, J. Anthony |
| spellingShingle |
McKee, Suzanne P. Levi, Dennis M. Schor, Clifton M. Movshon, J. Anthony Saccadic latency in amblyopia |
| author_facet |
McKee, Suzanne P. Levi, Dennis M. Schor, Clifton M. Movshon, J. Anthony |
| author_sort |
McKee, Suzanne P. |
| title |
Saccadic latency in amblyopia |
| title_short |
Saccadic latency in amblyopia |
| title_full |
Saccadic latency in amblyopia |
| title_fullStr |
Saccadic latency in amblyopia |
| title_full_unstemmed |
Saccadic latency in amblyopia |
| title_sort |
saccadic latency in amblyopia |
| description |
We measured saccadic latencies in a large sample (total n = 459) of individuals with amblyopia or risk factors for amblyopia, e.g., strabismus or anisometropia, and normal control subjects. We presented an easily visible target randomly to the left or right, 3.5° from fixation. The interocular difference in saccadic latency is highly correlated with the interocular difference in LogMAR (Snellen) acuity—as the acuity difference increases, so does the latency difference. Strabismic and strabismic-anisometropic amblyopes have, on average, a larger difference between their eyes in LogMAR acuity than anisometropic amblyopes and thus their interocular latency difference is, on average, significantly larger than anisometropic amblyopes. Despite its relation to LogMAR acuity, the longer latency in strabismic amblyopes cannot be attributed either to poor resolution or to reduced contrast sensitivity, because their interocular differences in grating acuity and in contrast sensitivity are roughly the same as for anisometropic amblyopes. The correlation between LogMAR acuity and saccadic latency arises because of the confluence of two separable effects in the strabismic amblyopic eye—poor letter recognition impairs LogMAR acuity while an intrinsic sluggishness delays reaction time. We speculate that the frequent microsaccades and the accompanying attentional shifts, made while strabismic amblyopes struggle to maintain fixation with their amblyopic eyes, result in all types of reactions being irreducibly delayed. |
| publisher |
The Association for Research in Vision and Ophthalmology |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089444/ |
| _version_ |
1613706933995307008 |