Defective Autophagy, Mitochondrial Clearance and Lipophagy in Niemann-Pick Type B Lymphocytes

Defective Autophagy, Mitochondrial Clearance and Lipophagy in Niemann-Pick Type B Lymphocytes

Niemann-Pick disease type A (NP-A) and type B (NP-B) are lysosomal storage diseases (LSDs) caused by sphingomyelin accumulation in lysosomes relying on reduced or absent acid sphingomyelinase. A considerable body of evidence suggests that lysosomal storage in many LSD impairs autophagy, resulting in...

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Bibliographic Details
Main Authors: Canonico, Barbara, Cesarini, Erica, Salucci, Sara, Luchetti, Francesca, Falcieri, Elisabetta, Di Sario, Gianna, Palma, Fulvio, Papa, Stefano
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087958/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087958/

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