miR-155: A Novel Target in Allergic Asthma
MicroRNAs (miRNAs), a class of small non-coding RNAs of 18–24 nucleotides in length, function to posttranscriptionally regulate protein expression. miR-155 was one of the first identified and, to date, the most studied miRNA, and has been linked to various cellular processes such as modulation of im...
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| Format: | Online |
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MDPI
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085797/ |
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pubmed-50857972016-11-01 miR-155: A Novel Target in Allergic Asthma Zhou, Hong Li, Junyao Gao, Peng Wang, Qi Zhang, Jie Review MicroRNAs (miRNAs), a class of small non-coding RNAs of 18–24 nucleotides in length, function to posttranscriptionally regulate protein expression. miR-155 was one of the first identified and, to date, the most studied miRNA, and has been linked to various cellular processes such as modulation of immune responses and oncogenesis. Previous studies have identified miR-155 as a crucial positive regulator of Th1 immune response in autoimmune diseases, but as a suppressor of Th2 immunity in allergic disorders. However, recent studies have found new evidence that miR-155 plays an indispensible role in allergic asthma. This review summarizes the recent findings with respect to miR-155 in immune responses and the underlying mechanisms responsible for miR-155-related allergic diseases, as well as the similarities between miR-155 and glucocorticoids in immunity. MDPI 2016-10-24 /pmc/articles/PMC5085797/ /pubmed/27783037 http://dx.doi.org/10.3390/ijms17101773 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zhou, Hong Li, Junyao Gao, Peng Wang, Qi Zhang, Jie |
| spellingShingle |
Zhou, Hong Li, Junyao Gao, Peng Wang, Qi Zhang, Jie miR-155: A Novel Target in Allergic Asthma |
| author_facet |
Zhou, Hong Li, Junyao Gao, Peng Wang, Qi Zhang, Jie |
| author_sort |
Zhou, Hong |
| title |
miR-155: A Novel Target in Allergic Asthma |
| title_short |
miR-155: A Novel Target in Allergic Asthma |
| title_full |
miR-155: A Novel Target in Allergic Asthma |
| title_fullStr |
miR-155: A Novel Target in Allergic Asthma |
| title_full_unstemmed |
miR-155: A Novel Target in Allergic Asthma |
| title_sort |
mir-155: a novel target in allergic asthma |
| description |
MicroRNAs (miRNAs), a class of small non-coding RNAs of 18–24 nucleotides in length, function to posttranscriptionally regulate protein expression. miR-155 was one of the first identified and, to date, the most studied miRNA, and has been linked to various cellular processes such as modulation of immune responses and oncogenesis. Previous studies have identified miR-155 as a crucial positive regulator of Th1 immune response in autoimmune diseases, but as a suppressor of Th2 immunity in allergic disorders. However, recent studies have found new evidence that miR-155 plays an indispensible role in allergic asthma. This review summarizes the recent findings with respect to miR-155 in immune responses and the underlying mechanisms responsible for miR-155-related allergic diseases, as well as the similarities between miR-155 and glucocorticoids in immunity. |
| publisher |
MDPI |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085797/ |
| _version_ |
1613703629660749824 |