SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells

SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells

Pancreatic ductal adenocarcinoma (PDAC) is a highly deadly malignancy. Expression of the stem cell transcription factor SOX2 increases during progression of PDAC. Knockdown of SOX2 in PDAC cell lines decreases growth in vitro; whereas, stable overexpression of SOX2 in one PDAC cell line reportedly i...

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Bibliographic Details
Main Authors: Wuebben, Erin L., Wilder, Phillip J., Cox, Jesse L., Grunkemeyer, James A., Caffrey, Thomas, Hollingsworth, Michael A., Rizzino, Angie
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085197/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085197/

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