Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells

Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells

Sterols are the important active ingredients of fungal secondary metabolites to induce death of tumor cells. In our previous study, we found that ergosterol peroxide (5α, 8α-epidioxiergosta-6, 22-dien-3β-ol), purified from Ganoderma lucidum, induced human cancer cell death. Since the amount of purif...

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Bibliographic Details
Main Authors: Li, Xiangmin, Wu, Qingping, Bu, Ming, Hu, Liming, Du, William W., Jiao, Chunwei, Pan, Honghui, Sdiri, Mouna, Wu, Nan, Xie, Yizhen, Yang, Burton B.
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085130/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085130/

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