Protective effect of silymarin against chemical-induced cardiotoxicity
Cardiac disorders remain one of the most important causes of death in the world. Oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. Recently, several natural products have been utilized in different studies with the aim to protect the pr...
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Mashhad University of Medical Sciences
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080420/ |
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pubmed-50804202016-11-01 Protective effect of silymarin against chemical-induced cardiotoxicity Razavi, Bibi Marjan Karimi, Gholamreza Review Article Cardiac disorders remain one of the most important causes of death in the world. Oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. Recently, several natural products have been utilized in different studies with the aim to protect the progression of oxidative stress-induced cardiac disorders. There is a large body of evidence that administration of antioxidants may be useful in ameliorating cardiac toxicity. Silymarin, a polyphenolic flavonoid has been shown to have utility in several cardiovascular disorders. In this review, various studies in scientific databases regarding the preventive effects of silymarin against cardiotoxicity induced by chemicals were introduced. Although there are many studies representing the valuable effects of silymarin in different diseases, the number of researches relating to the possible cardiac protective effects of silymarin against drugs induced toxicity is rather limited. Results of these studies show that silymarin has a broad spectrum of cardiac protective activity against toxicity induced by some chemicals including metals, environmental pollutants, oxidative agents and anticancer drugs. Further studies are needed to establish the utility of silymarin in protection against cardiac toxicity. Mashhad University of Medical Sciences 2016-09 /pmc/articles/PMC5080420/ /pubmed/27803777 Text en Copyright: © Iranian Journal of Basic Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Razavi, Bibi Marjan Karimi, Gholamreza |
| spellingShingle |
Razavi, Bibi Marjan Karimi, Gholamreza Protective effect of silymarin against chemical-induced cardiotoxicity |
| author_facet |
Razavi, Bibi Marjan Karimi, Gholamreza |
| author_sort |
Razavi, Bibi Marjan |
| title |
Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_short |
Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_full |
Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_fullStr |
Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_full_unstemmed |
Protective effect of silymarin against chemical-induced cardiotoxicity |
| title_sort |
protective effect of silymarin against chemical-induced cardiotoxicity |
| description |
Cardiac disorders remain one of the most important causes of death in the world. Oxidative stress has been suggested as one of the molecular mechanisms involved in drug-induced cardiac toxicity. Recently, several natural products have been utilized in different studies with the aim to protect the progression of oxidative stress-induced cardiac disorders. There is a large body of evidence that administration of antioxidants may be useful in ameliorating cardiac toxicity. Silymarin, a polyphenolic flavonoid has been shown to have utility in several cardiovascular disorders. In this review, various studies in scientific databases regarding the preventive effects of silymarin against cardiotoxicity induced by chemicals were introduced. Although there are many studies representing the valuable effects of silymarin in different diseases, the number of researches relating to the possible cardiac protective effects of silymarin against drugs induced toxicity is rather limited. Results of these studies show that silymarin has a broad spectrum of cardiac protective activity against toxicity induced by some chemicals including metals, environmental pollutants, oxidative agents and anticancer drugs. Further studies are needed to establish the utility of silymarin in protection against cardiac toxicity. |
| publisher |
Mashhad University of Medical Sciences |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080420/ |
| _version_ |
1613698371983245312 |