Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel–Lindau tumour suppressor (VHL) and unrestrained activation of hypoxia-inducible transcription factors (HIFs). Genetic and epigenetic determinants have an impact on HIF pathways. A recent genome-wide associ...

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Bibliographic Details
Main Authors: Grampp, Steffen, Platt, James L., Lauer, Victoria, Salama, Rafik, Kranz, Franziska, Neumann, Viviana K., Wach, Sven, Stöhr, Christine, Hartmann, Arndt, Eckardt, Kai-Uwe, Ratcliffe, Peter J., Mole, David R., Schödel, Johannes
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079059/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079059/

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