Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-κB signaling

Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-κB signaling

The aberrant expression of microRNAs (miRNAs) has emerged as an important hallmark of cancer. However, the molecular mechanisms underlying the changes in miRNA expression remain unclear. In this study, we discovered a novel epigenetic mechanism of miR-506 regulation and investigated its functional s...

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Bibliographic Details
Main Authors: Li, J, Wu, H, Li, W, Yin, L, Guo, S, Xu, X, Ouyang, Y, Zhao, Z, Liu, S, Tian, Y, Tian, Z, Ju, J, Ni, B, Wang, H
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078861/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078861/

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