Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution

Solid tumors often display chemotherapy resistance. Pancreatic ductal adenocarcinoma (PDAC) is the archetype of resistant tumors as current chemotherapies are inefficient. The tumor stroma and extracellular matrix (ECM) are key contributors to PDAC aggressiveness and to limiting the efficacy of chem...

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Bibliographic Details
Main Authors: Le Calvé, Benjamin, Griveau, Audrey, Vindrieux, David, Maréchal, Raphaël, Wiel, Clotilde, Svrcek, Magali, Gout, Johann, Azzi, Lamia, Payen, Léa, Cros, Jérôme, de la Fouchardière, Christelle, Dubus, Pierre, Guitton, Jérôme, Bartholin, Laurent, Bachet, Jean-Baptiste, Bernard, David
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078000/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078000/

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