Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid

Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by extremely heterogeneous molecular and biologic abnormalities that hamper the development of effective targeted treatment modalities. While AML cells are highly sensitive to cytotoxic Ca2+ overload, the feasibility...

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Bibliographic Details
Main Authors: Pesakhov, Stella, Nachliely, Matan, Barvish, Zeev, Aqaqe, Nasma, Schwartzman, Bar, Voronov, Elena, Sharoni, Yoav, Studzinski, George P., Fishman, Daniel, Danilenko, Michael
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077981/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077981/

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