REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model

The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is demonstrated that the Radio Electric Asymmetric Con...

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Main Authors:	Luca, Lorenzini, Alessandro, Giuliani, Sandra, Sivilia, Antonio, Baldassarro Vito, Mercedes, Fernandez, Matteo, Lotti Margotti, Luciana, Giardino, Vania, Fontani, Salvatore, Rinaldi, Laura, Calzà
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075930/

id	pubmed-5075930
recordtype	oai_dc
spelling	pubmed-50759302016-10-28 REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model Luca, Lorenzini Alessandro, Giuliani Sandra, Sivilia Antonio, Baldassarro Vito Mercedes, Fernandez Matteo, Lotti Margotti Luciana, Giardino Vania, Fontani Salvatore, Rinaldi Laura, Calzà Article The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is demonstrated that the Radio Electric Asymmetric Conveyer (REAC), an innovative technology platform for neuro- and bio-modulation, used according to the neuro-regenerative protocol (RGN-N), significantly increases astroglial reaction around the amyloid plaques in an AD mouse model, as evaluated by GFAP-immunoreactivity, and reduces microglia-associated neuroinflammation markers, as evaluated by Iba1-immunoreactivity and mRNA expression level of inflammatory cytokines TREM. IL1beta, iNOS and MRC1 were not affected neither by the genotype or by REAC RGN-N treatment. Also observed was an increase in locomotion in treated animals. The study was performed in 24-month-old male Tg2576 mice and age-matching wild-type animals, tested for Y-maze, contextual fear conditioning and locomotion immediately after the end of a specific REAC treatment administered for 15 hours/day for 15 days. These results demonstrated that REAC RGN-N treatment modifies pathological neuroinflammation, and mitigates part of the complex motor behaviour alterations observed in very old Tg2576 mice. Nature Publishing Group 2016-10-24 /pmc/articles/PMC5075930/ /pubmed/27775040 http://dx.doi.org/10.1038/srep35719 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Luca, Lorenzini Alessandro, Giuliani Sandra, Sivilia Antonio, Baldassarro Vito Mercedes, Fernandez Matteo, Lotti Margotti Luciana, Giardino Vania, Fontani Salvatore, Rinaldi Laura, Calzà
spellingShingle	Luca, Lorenzini Alessandro, Giuliani Sandra, Sivilia Antonio, Baldassarro Vito Mercedes, Fernandez Matteo, Lotti Margotti Luciana, Giardino Vania, Fontani Salvatore, Rinaldi Laura, Calzà REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model
author_facet	Luca, Lorenzini Alessandro, Giuliani Sandra, Sivilia Antonio, Baldassarro Vito Mercedes, Fernandez Matteo, Lotti Margotti Luciana, Giardino Vania, Fontani Salvatore, Rinaldi Laura, Calzà
author_sort	Luca, Lorenzini
title	REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model
title_short	REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model
title_full	REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model
title_fullStr	REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model
title_full_unstemmed	REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model
title_sort	reac technology modifies pathological neuroinflammation and motor behaviour in an alzheimer’s disease mouse model
description	The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is demonstrated that the Radio Electric Asymmetric Conveyer (REAC), an innovative technology platform for neuro- and bio-modulation, used according to the neuro-regenerative protocol (RGN-N), significantly increases astroglial reaction around the amyloid plaques in an AD mouse model, as evaluated by GFAP-immunoreactivity, and reduces microglia-associated neuroinflammation markers, as evaluated by Iba1-immunoreactivity and mRNA expression level of inflammatory cytokines TREM. IL1beta, iNOS and MRC1 were not affected neither by the genotype or by REAC RGN-N treatment. Also observed was an increase in locomotion in treated animals. The study was performed in 24-month-old male Tg2576 mice and age-matching wild-type animals, tested for Y-maze, contextual fear conditioning and locomotion immediately after the end of a specific REAC treatment administered for 15 hours/day for 15 days. These results demonstrated that REAC RGN-N treatment modifies pathological neuroinflammation, and mitigates part of the complex motor behaviour alterations observed in very old Tg2576 mice.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075930/
_version_	1613694116327063552

REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model

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