The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases
The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) comprise a family of secreted zinc metalloproteinases with a precisely ordered modular organization. These enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their dysregul...
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| Format: | Online |
| Language: | English |
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Dove Medical Press
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074720/ |
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pubmed-5074720 |
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pubmed-50747202016-10-27 The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases Lin, Edward A Liu, Chuan-ju Review The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) comprise a family of secreted zinc metalloproteinases with a precisely ordered modular organization. These enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their dysregulation has been implicated in disease-related processes such as arthritis, atherosclerosis, cancer, and inflammation. ADAMTS-7 and ADAMTS-12 share a similar domain organization to each other and form a subgroup within the ADAMTS family. Emerging evidence suggests that ADAMTS-7 and ADAMTS-12 may play an important role in the development and pathogenesis of various kinds of diseases. In this review, we summarize what is currently known about the roles of these two metalloproteinases, with a special focus on their involvement in chondrogenesis, endochondral ossification, and the pathogenesis of arthritis, atherosclerosis, and cancer. The future study of ADAMTS-7 and ADAMTS-12, as well as the molecules with which they interact, will help us to better understand a variety of human diseases from both a biological and therapeutic standpoint. Dove Medical Press 2009-09-22 /pmc/articles/PMC5074720/ /pubmed/27789986 Text en © 2009 Lin and Liu, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lin, Edward A Liu, Chuan-ju |
| spellingShingle |
Lin, Edward A Liu, Chuan-ju The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases |
| author_facet |
Lin, Edward A Liu, Chuan-ju |
| author_sort |
Lin, Edward A |
| title |
The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases |
| title_short |
The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases |
| title_full |
The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases |
| title_fullStr |
The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases |
| title_full_unstemmed |
The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases |
| title_sort |
emerging roles of adamts-7 and adamts-12 matrix metalloproteinases |
| description |
The a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) comprise a family of secreted zinc metalloproteinases with a precisely ordered modular organization. These enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their dysregulation has been implicated in disease-related processes such as arthritis, atherosclerosis, cancer, and inflammation. ADAMTS-7 and ADAMTS-12 share a similar domain organization to each other and form a subgroup within the ADAMTS family. Emerging evidence suggests that ADAMTS-7 and ADAMTS-12 may play an important role in the development and pathogenesis of various kinds of diseases. In this review, we summarize what is currently known about the roles of these two metalloproteinases, with a special focus on their involvement in chondrogenesis, endochondral ossification, and the pathogenesis of arthritis, atherosclerosis, and cancer. The future study of ADAMTS-7 and ADAMTS-12, as well as the molecules with which they interact, will help us to better understand a variety of human diseases from both a biological and therapeutic standpoint. |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074720/ |
| _version_ |
1613693091153182720 |