Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease

Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in the metabolism of therapeutic drugs. On a daily basis, however, we are exposed to one of the most abundant substrates of the enzyme trimethylamine (TMA), which is released from various dietary components by the acti...

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Bibliographic Details
Main Authors: Fennema, Diede, Phillips, Ian R., Shephard, Elizabeth A.
Format: Online
Language:English
Published: The American Society for Pharmacology and Experimental Therapeutics 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074467/