Post‐transcriptional gene regulation in the biology and virulence of Candida albicans
In the human fungal pathogen Candida albicans, remodelling of gene expression drives host adaptation and virulence. Recent studies revealed that in addition to transcription, post‐transcriptional mRNA control plays important roles in virulence‐related pathways. Hyphal morphogenesis, biofilm formatio...
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John Wiley and Sons Inc.
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074327/ |
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pubmed-50743272016-11-04 Post‐transcriptional gene regulation in the biology and virulence of Candida albicans Verma‐Gaur, Jiyoti Traven, Ana Microreviews In the human fungal pathogen Candida albicans, remodelling of gene expression drives host adaptation and virulence. Recent studies revealed that in addition to transcription, post‐transcriptional mRNA control plays important roles in virulence‐related pathways. Hyphal morphogenesis, biofilm formation, stress responses, antifungal drug susceptibility and virulence in animal models require post‐transcriptional regulators. This includes RNA binding proteins that control mRNA localization, decay and translation, as well as the cytoplasmic mRNA decay pathway. Comprehensive understanding of how modulation of gene expression networks drives C. albicans virulence will necessitate integration of our knowledge on transcriptional and post‐transcriptional mRNA control. John Wiley and Sons Inc. 2016-04-14 2016-06 /pmc/articles/PMC5074327/ /pubmed/26999710 http://dx.doi.org/10.1111/cmi.12593 Text en © 2016 The Authors Cellular Microbiology Published by John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
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Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Verma‐Gaur, Jiyoti Traven, Ana |
| spellingShingle |
Verma‐Gaur, Jiyoti Traven, Ana Post‐transcriptional gene regulation in the biology and virulence of Candida albicans |
| author_facet |
Verma‐Gaur, Jiyoti Traven, Ana |
| author_sort |
Verma‐Gaur, Jiyoti |
| title |
Post‐transcriptional gene regulation in the biology and virulence of Candida albicans
|
| title_short |
Post‐transcriptional gene regulation in the biology and virulence of Candida albicans
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| title_full |
Post‐transcriptional gene regulation in the biology and virulence of Candida albicans
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| title_fullStr |
Post‐transcriptional gene regulation in the biology and virulence of Candida albicans
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| title_full_unstemmed |
Post‐transcriptional gene regulation in the biology and virulence of Candida albicans
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| title_sort |
post‐transcriptional gene regulation in the biology and virulence of candida albicans |
| description |
In the human fungal pathogen Candida albicans, remodelling of gene expression drives host adaptation and virulence. Recent studies revealed that in addition to transcription, post‐transcriptional mRNA control plays important roles in virulence‐related pathways. Hyphal morphogenesis, biofilm formation, stress responses, antifungal drug susceptibility and virulence in animal models require post‐transcriptional regulators. This includes RNA binding proteins that control mRNA localization, decay and translation, as well as the cytoplasmic mRNA decay pathway. Comprehensive understanding of how modulation of gene expression networks drives C. albicans virulence will necessitate integration of our knowledge on transcriptional and post‐transcriptional mRNA control. |
| publisher |
John Wiley and Sons Inc. |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074327/ |
| _version_ |
1613692843011866624 |