Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes

The recent success in ribosome structure determination by cryoEM has opened the door to defining structural differences between ribosomes of pathogenic organisms and humans and to understand ribosome-targeting antibiotics. Here, by direct electron-counting cryoEM, we have determined the structures o...

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Bibliographic Details
Main Authors: Zhang, Xing, Lai, Mason, Chang, Winston, Yu, Iris, Ding, Ke, Mrazek, Jan, Ng, Hwee L., Yang, Otto O., Maslov, Dmitri A., Zhou, Z. Hong
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071889/