White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure
White matter disease in the brain increases with age and cardiovascular disease, emerging in midlife, and these associations may be influenced by both genetic and environmental factors. We examined the frequency, distribution, and heritability of abnormal white matter and its association with hypert...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Elsevier
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071546/ |
| id |
pubmed-5071546 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-50715462016-10-27 White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure Fennema-Notestine, Christine McEvoy, Linda K. Notestine, Randy Panizzon, Matthew S. Yau, Wai-Ying Wendy Franz, Carol E. Lyons, Michael J. Eyler, Lisa T. Neale, Michael C. Xian, Hong McKenzie, Ruth E. Kremen, William S. Regular Article White matter disease in the brain increases with age and cardiovascular disease, emerging in midlife, and these associations may be influenced by both genetic and environmental factors. We examined the frequency, distribution, and heritability of abnormal white matter and its association with hypertension in 395 middle-aged male twins (61.9 ± 2.6 years) from the Vietnam Era Twin Study of Aging, 67% of whom were hypertensive. A multi-channel segmentation approach estimated abnormal regions within the white matter. Using multivariable regression models, we characterized the frequency distribution of abnormal white matter in midlife and investigated associations with hypertension and Apolipoprotein E-ε4 status and the impact of duration and control of hypertension. Then, using the classical twin design, we estimated abnormal white matter heritability and the extent of shared genetic overlap with blood pressure. Abnormal white matter was predominantly located in periventricular and deep parietal and frontal regions; associated with age (t = 1.9, p = 0.05) and hypertension (t = 2.9, p = 0.004), but not Apolipoprotein ε4 status; and was greater in those with uncontrolled hypertension relative to controlled (t = 3.0, p = 0.003) and normotensive (t = 4.0, p = 0.0001) groups, suggesting that abnormal white matter may reflect currently active cerebrovascular effects. Abnormal white matter was highly heritable (a2 = 0.81) and shared some genetic influences with systolic blood pressure (rA = 0.26), although there was evidence for distinct genetic contributions and unique environmental influences. Future longitudinal research will shed light on factors impacting white matter disease presentation, progression, and potential recovery. Elsevier 2016-10-06 /pmc/articles/PMC5071546/ /pubmed/27790395 http://dx.doi.org/10.1016/j.nicl.2016.10.001 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Fennema-Notestine, Christine McEvoy, Linda K. Notestine, Randy Panizzon, Matthew S. Yau, Wai-Ying Wendy Franz, Carol E. Lyons, Michael J. Eyler, Lisa T. Neale, Michael C. Xian, Hong McKenzie, Ruth E. Kremen, William S. |
| spellingShingle |
Fennema-Notestine, Christine McEvoy, Linda K. Notestine, Randy Panizzon, Matthew S. Yau, Wai-Ying Wendy Franz, Carol E. Lyons, Michael J. Eyler, Lisa T. Neale, Michael C. Xian, Hong McKenzie, Ruth E. Kremen, William S. White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure |
| author_facet |
Fennema-Notestine, Christine McEvoy, Linda K. Notestine, Randy Panizzon, Matthew S. Yau, Wai-Ying Wendy Franz, Carol E. Lyons, Michael J. Eyler, Lisa T. Neale, Michael C. Xian, Hong McKenzie, Ruth E. Kremen, William S. |
| author_sort |
Fennema-Notestine, Christine |
| title |
White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure |
| title_short |
White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure |
| title_full |
White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure |
| title_fullStr |
White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure |
| title_full_unstemmed |
White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure |
| title_sort |
white matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure |
| description |
White matter disease in the brain increases with age and cardiovascular disease, emerging in midlife, and these associations may be influenced by both genetic and environmental factors. We examined the frequency, distribution, and heritability of abnormal white matter and its association with hypertension in 395 middle-aged male twins (61.9 ± 2.6 years) from the Vietnam Era Twin Study of Aging, 67% of whom were hypertensive. A multi-channel segmentation approach estimated abnormal regions within the white matter. Using multivariable regression models, we characterized the frequency distribution of abnormal white matter in midlife and investigated associations with hypertension and Apolipoprotein E-ε4 status and the impact of duration and control of hypertension. Then, using the classical twin design, we estimated abnormal white matter heritability and the extent of shared genetic overlap with blood pressure. Abnormal white matter was predominantly located in periventricular and deep parietal and frontal regions; associated with age (t = 1.9, p = 0.05) and hypertension (t = 2.9, p = 0.004), but not Apolipoprotein ε4 status; and was greater in those with uncontrolled hypertension relative to controlled (t = 3.0, p = 0.003) and normotensive (t = 4.0, p = 0.0001) groups, suggesting that abnormal white matter may reflect currently active cerebrovascular effects. Abnormal white matter was highly heritable (a2 = 0.81) and shared some genetic influences with systolic blood pressure (rA = 0.26), although there was evidence for distinct genetic contributions and unique environmental influences. Future longitudinal research will shed light on factors impacting white matter disease presentation, progression, and potential recovery. |
| publisher |
Elsevier |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071546/ |
| _version_ |
1613690445871710208 |