Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter

During infection, pathogenic bacteria face an adverse environment of factors driven by both cellular and humoral defense mechanisms. To help evade the immune response and ultimately proliferate inside the host, many bacteria evolved specialized secretion systems to deliver effector proteins directly...

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Main Authors:	Sontag, Ryan L., Nakayasu, Ernesto S., Brown, Roslyn N., Niemann, George S., Sydor, Michael A., Sanchez, Octavio, Ansong, Charles, Lu, Shao-Yeh, Choi, Hyungwon, Valleau, Dylan, Weitz, Karl K., Savchenko, Alexei, Cambronne, Eric D., Adkins, Joshua N.
Format:	Online
Language:	English
Published:	American Society for Microbiology 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069955/

id	pubmed-5069955
recordtype	oai_dc
spelling	pubmed-50699552016-11-07 Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter Sontag, Ryan L. Nakayasu, Ernesto S. Brown, Roslyn N. Niemann, George S. Sydor, Michael A. Sanchez, Octavio Ansong, Charles Lu, Shao-Yeh Choi, Hyungwon Valleau, Dylan Weitz, Karl K. Savchenko, Alexei Cambronne, Eric D. Adkins, Joshua N. Research Article During infection, pathogenic bacteria face an adverse environment of factors driven by both cellular and humoral defense mechanisms. To help evade the immune response and ultimately proliferate inside the host, many bacteria evolved specialized secretion systems to deliver effector proteins directly into host cells. Translocated effector proteins function to subvert host defense mechanisms. Numerous pathogenic bacteria use a specialized secretion system called type III secretion to deliver effectors into the host cell cytosol. Here, we identified 75 new host targets of Salmonella and Citrobacter effectors, which will help elucidate their mechanisms of action. American Society for Microbiology 2016-07-12 /pmc/articles/PMC5069955/ /pubmed/27822540 http://dx.doi.org/10.1128/mSystems.00032-15 Text en Copyright © 2016 Sontag et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) .
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sontag, Ryan L. Nakayasu, Ernesto S. Brown, Roslyn N. Niemann, George S. Sydor, Michael A. Sanchez, Octavio Ansong, Charles Lu, Shao-Yeh Choi, Hyungwon Valleau, Dylan Weitz, Karl K. Savchenko, Alexei Cambronne, Eric D. Adkins, Joshua N.
spellingShingle	Sontag, Ryan L. Nakayasu, Ernesto S. Brown, Roslyn N. Niemann, George S. Sydor, Michael A. Sanchez, Octavio Ansong, Charles Lu, Shao-Yeh Choi, Hyungwon Valleau, Dylan Weitz, Karl K. Savchenko, Alexei Cambronne, Eric D. Adkins, Joshua N. Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter
author_facet	Sontag, Ryan L. Nakayasu, Ernesto S. Brown, Roslyn N. Niemann, George S. Sydor, Michael A. Sanchez, Octavio Ansong, Charles Lu, Shao-Yeh Choi, Hyungwon Valleau, Dylan Weitz, Karl K. Savchenko, Alexei Cambronne, Eric D. Adkins, Joshua N.
author_sort	Sontag, Ryan L.
title	Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter
title_short	Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter
title_full	Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter
title_fullStr	Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter
title_full_unstemmed	Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter
title_sort	identification of novel host interactors of effectors secreted by salmonella and citrobacter
description	During infection, pathogenic bacteria face an adverse environment of factors driven by both cellular and humoral defense mechanisms. To help evade the immune response and ultimately proliferate inside the host, many bacteria evolved specialized secretion systems to deliver effector proteins directly into host cells. Translocated effector proteins function to subvert host defense mechanisms. Numerous pathogenic bacteria use a specialized secretion system called type III secretion to deliver effectors into the host cell cytosol. Here, we identified 75 new host targets of Salmonella and Citrobacter effectors, which will help elucidate their mechanisms of action.
publisher	American Society for Microbiology
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069955/
_version_	1613689157130911744

Identification of Novel Host Interactors of Effectors Secreted by Salmonella and Citrobacter

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