Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination

Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination

Central memory T cell (Tcm) and polyfunctional CD4 T cell responses contribute to vaccine-elicited protection with both human and bovine tuberculosis (TB); however, their combined role in protective immunity to TB is unclear. To address this question, we evaluated polyfunctional cytokine responses b...

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Bibliographic Details
Main Authors: Maggioli, Mayara F., Palmer, Mitchell V., Thacker, Tyler C., Vordermeier, Hans Martin, McGill, Jodi L., Whelan, Adam O., Larsen, Michelle H., Jacobs, William R., Waters, W. Ray
Format: Online
Language:English
Published: Frontiers Media S.A. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066095/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066095/

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