Physical Properties and Effect in a Battery of Safety Pharmacology Models for Three Structurally Distinct Enteric Polymers Employed as Spray-Dried Dispersion Carriers
Establishing a wide therapeutic index (TI) for pre-clinical safety is important during lead optimization (LO) in research, prior to clinical development, although is often limited by a molecules physiochemical characteristics. Recent advances in the application of the innovative vibrating mesh spray...
Main Authors: | Fryer, Ryan M., Patel, Mita, Zhang, Xiaomei, Baum-Kroker, Katja S., Muthukumarana, Akalushi, Linehan, Brian, Tseng, Yin-Chao |
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Format: | Online |
Language: | English |
Published: |
Frontiers Media S.A.
2016
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062032/ |
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