High-throughput fingerprinting of human pluripotent stem cell factor responsiveness and lineage induction bias

Populations of cells create local environments that lead to emergent heterogeneity. This is particularly evident in human pluripotent stem cells (hPSCs) where microenvironmental heterogeneity limits cell fate control. We have developed a high-throughput platform to screen hPSCs in configurable micro...

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Bibliographic Details
Main Authors: Nazareth, Emanuel J.P., Ostblom, Joel E.E., Lücker, Petra B., Shukla, Shreya, Alvarez, Manuel M., Oh, Steve K.W., Yin, Ting, Zandstra, Peter W.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061564/