Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation

Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation

Selenocysteine is the only proteinogenic amino acid encoded by a recoded in-frame UGA codon that does not operate as the canonical opal stop codon. A specialized translation elongation factor, eEFSec in eukaryotes and SelB in prokaryotes, promotes selenocysteine incorporation into selenoproteins by...

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Bibliographic Details
Main Authors: Dobosz-Bartoszek, Malgorzata, Pinkerton, Mark H., Otwinowski, Zbyszek, Chakravarthy, Srinivas, Söll, Dieter, Copeland, Paul R., Simonović, Miljan
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059743/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059743/

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