Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis

Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of...

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Main Authors:	Wang, Ying, Wang, Lili, Yang, Haoyu, Yuan, Weichang, Ren, Jingyi, Bai, Yanping
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059604/

id	pubmed-5059604
recordtype	oai_dc
spelling	pubmed-50596042016-10-23 Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis Wang, Ying Wang, Lili Yang, Haoyu Yuan, Weichang Ren, Jingyi Bai, Yanping Research Article Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were compared between patients with psoriasis vulgaris and healthy controls, and the infiltration of Tfh cells was detected between lesional and nonlesional skin tissues of psoriasis patients. Moreover, the dynamic change of cTfh cells before and after acitretin treatment was evaluated. Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-γ) of cTfh cells in psoriasis patients. Compared with nonlesional skin tissues of psoriasis patients, the number of infiltrated Tfh cells was significantly increased in psoriasis lesions. In addition, positive correlations between the percentage of cTfh, functional markers on cTfh cells in peripheral blood and disease severity were noted. Furthermore, the frequency of cTfh cells and the levels of cytokines secreted by cTfh cells were all significantly decreased after 1-month treatment. Hindawi Publishing Corporation 2016 2016-09-28 /pmc/articles/PMC5059604/ /pubmed/27774460 http://dx.doi.org/10.1155/2016/7346030 Text en Copyright © 2016 Ying Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wang, Ying Wang, Lili Yang, Haoyu Yuan, Weichang Ren, Jingyi Bai, Yanping
spellingShingle	Wang, Ying Wang, Lili Yang, Haoyu Yuan, Weichang Ren, Jingyi Bai, Yanping Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis
author_facet	Wang, Ying Wang, Lili Yang, Haoyu Yuan, Weichang Ren, Jingyi Bai, Yanping
author_sort	Wang, Ying
title	Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis
title_short	Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis
title_full	Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis
title_fullStr	Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis
title_full_unstemmed	Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis
title_sort	activated circulating t follicular helper cells are associated with disease severity in patients with psoriasis
description	Circulating T follicular helper (cTfh) cells are known to be involved in numerous immune-mediated diseases, but their pathological role in psoriasis is less fully investigated. Herein, we aimed to identify whether cTfh cells contributed to the pathogenesis of psoriasis. The frequency and function of cTfh cells were compared between patients with psoriasis vulgaris and healthy controls, and the infiltration of Tfh cells was detected between lesional and nonlesional skin tissues of psoriasis patients. Moreover, the dynamic change of cTfh cells before and after acitretin treatment was evaluated. Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-γ) of cTfh cells in psoriasis patients. Compared with nonlesional skin tissues of psoriasis patients, the number of infiltrated Tfh cells was significantly increased in psoriasis lesions. In addition, positive correlations between the percentage of cTfh, functional markers on cTfh cells in peripheral blood and disease severity were noted. Furthermore, the frequency of cTfh cells and the levels of cytokines secreted by cTfh cells were all significantly decreased after 1-month treatment.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059604/
_version_	1613680759512498176

Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis

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