Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma

Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma

The miR-145-5p, which induces TP53-dependent apoptosis, is down-regulated in several tumors, including hepatocellular carcinomas (HCCs), but some HCCs show physiological expression of this miR. Here we demonstrate that in HCC cells carrying wild-type TP53 the steady activation of the miR-145 signali...

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Bibliographic Details
Main Authors: Lupini, Laura, Pepe, Felice, Ferracin, Manuela, Braconi, Chiara, Callegari, Elisa, Pagotto, Sara, Spizzo, Riccardo, Zagatti, Barbara, Lanuti, Paola, Fornari, Francesca, Ghasemi, Reza, Mariani-Costantini, Renato, Bolondi, Luigi, Gramantieri, Laura, Calin, George A., Sabbioni, Silvia, Visone, Rosa, Veronese, Angelo, Negrini, Massimo
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058762/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058762/

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