Time-course of coherence in the human basal ganglia during voluntary movements

We are interested in characterizing how brain networks interact and communicate with each other during voluntary movements. We recorded electrical activities from the globus pallidus pars interna (GPi), subthalamic nucleus (STN) and the motor cortex during voluntary wrist movements. Seven patients w...

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Main Authors:	Talakoub, Omid, Neagu, Bogdan, Udupa, Kaviraja, Tsang, Eric, Chen, Robert, Popovic, Milos R., Wong, Willy
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057143/

id	pubmed-5057143
recordtype	oai_dc
spelling	pubmed-50571432016-10-24 Time-course of coherence in the human basal ganglia during voluntary movements Talakoub, Omid Neagu, Bogdan Udupa, Kaviraja Tsang, Eric Chen, Robert Popovic, Milos R. Wong, Willy Article We are interested in characterizing how brain networks interact and communicate with each other during voluntary movements. We recorded electrical activities from the globus pallidus pars interna (GPi), subthalamic nucleus (STN) and the motor cortex during voluntary wrist movements. Seven patients with dystonia and six patients with Parkinson’s disease underwent bilateral deep brain stimulation (DBS) electrode placement. Local field potentials from the DBS electrodes and scalp EEG from the electrodes placed over the motor cortices were recorded while the patients performed externally triggered and self-initiated movements. The coherence calculated between the motor cortex and STN or GPi was found to be coupled to its power in both the beta and the gamma bands. The association of coherence with power suggests that a coupling in neural activity between the basal ganglia and the motor cortex is required for the execution of voluntary movements. Finally, we propose a mathematical model involving coupled neural oscillators which provides a possible explanation for how inter-regional coupling takes place. Nature Publishing Group 2016-10-11 /pmc/articles/PMC5057143/ /pubmed/27725721 http://dx.doi.org/10.1038/srep34930 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Talakoub, Omid Neagu, Bogdan Udupa, Kaviraja Tsang, Eric Chen, Robert Popovic, Milos R. Wong, Willy
spellingShingle	Talakoub, Omid Neagu, Bogdan Udupa, Kaviraja Tsang, Eric Chen, Robert Popovic, Milos R. Wong, Willy Time-course of coherence in the human basal ganglia during voluntary movements
author_facet	Talakoub, Omid Neagu, Bogdan Udupa, Kaviraja Tsang, Eric Chen, Robert Popovic, Milos R. Wong, Willy
author_sort	Talakoub, Omid
title	Time-course of coherence in the human basal ganglia during voluntary movements
title_short	Time-course of coherence in the human basal ganglia during voluntary movements
title_full	Time-course of coherence in the human basal ganglia during voluntary movements
title_fullStr	Time-course of coherence in the human basal ganglia during voluntary movements
title_full_unstemmed	Time-course of coherence in the human basal ganglia during voluntary movements
title_sort	time-course of coherence in the human basal ganglia during voluntary movements
description	We are interested in characterizing how brain networks interact and communicate with each other during voluntary movements. We recorded electrical activities from the globus pallidus pars interna (GPi), subthalamic nucleus (STN) and the motor cortex during voluntary wrist movements. Seven patients with dystonia and six patients with Parkinson’s disease underwent bilateral deep brain stimulation (DBS) electrode placement. Local field potentials from the DBS electrodes and scalp EEG from the electrodes placed over the motor cortices were recorded while the patients performed externally triggered and self-initiated movements. The coherence calculated between the motor cortex and STN or GPi was found to be coupled to its power in both the beta and the gamma bands. The association of coherence with power suggests that a coupling in neural activity between the basal ganglia and the motor cortex is required for the execution of voluntary movements. Finally, we propose a mathematical model involving coupled neural oscillators which provides a possible explanation for how inter-regional coupling takes place.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057143/
_version_	1613678497231798272

Time-course of coherence in the human basal ganglia during voluntary movements

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