IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis determines patient prognosis; however, effective treatment for fibrosis has not been established. Oxidative stress and inflammation activate hepatic stellate cells (HSCs) and promote fibrosis. In contrast, cellular senescence inhi...

Full description

Bibliographic Details
Main Authors: Nishizawa, Hitoshi, Iguchi, Genzo, Fukuoka, Hidenori, Takahashi, Michiko, Suda, Kentaro, Bando, Hironori, Matsumoto, Ryusaku, Yoshida, Kenichi, Odake, Yukiko, Ogawa, Wataru, Takahashi, Yutaka
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056388/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056388/

Similar Items