The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint

Background. We studied the role of pulmonary veins in cancer progression using computed tomography (CT) scans. Methods. We obtained data from 260 patients with pulmonary vein obstruction syndrome (PVOS). We used CT scans to investigate pulmonary lesions in relation to pulmonary veins. We divided th...

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Main Authors:	Liaw, Chuang-Chi, Chang, Hung, Liao, Tzu-Yao, Wen, Ming-Sheng, Yu, Chih-Teng, Juan, Yu-Hsiang
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055964/

id	pubmed-5055964
recordtype	oai_dc
spelling	pubmed-50559642016-10-16 The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint Liaw, Chuang-Chi Chang, Hung Liao, Tzu-Yao Wen, Ming-Sheng Yu, Chih-Teng Juan, Yu-Hsiang Research Article Background. We studied the role of pulmonary veins in cancer progression using computed tomography (CT) scans. Methods. We obtained data from 260 patients with pulmonary vein obstruction syndrome (PVOS). We used CT scans to investigate pulmonary lesions in relation to pulmonary veins. We divided the lesions into central and peripheral lesions by their anatomical location: in the lung parenchymal tissue or pulmonary vein; in the superior or inferior pulmonary vein; and by unilateral or bilateral presence in the lungs. Results. Of the 260 PVOS patients, 226 (87%) had central lesions, 231 (89%) had peripheral lesions, and 190 (75%) had mixed central and peripheral lesions. Among the 226 central lesions, 93% had lesions within the superior pulmonary vein, either bilaterally or unilaterally. Among the 231 peripheral lesions, 65% involved bilateral lungs, 70% involved lesions within the inferior pulmonary veins, and 23% had obvious metastatic extensions into the left atrium. All patients exhibited nodules within their pulmonary veins. The predeath status included respiratory failure (40%) and loss of consciousness (60%). Conclusion. CT scans play an important role in following tumor progression within pulmonary veins. Besides respiratory distress, PVOS cancer cells entering centrally can result in cardiac and cerebral events and loss of consciousness or can metastasize peripherally from the pulmonary veins to the lungs. Hindawi Publishing Corporation 2016 2016-09-22 /pmc/articles/PMC5055964/ /pubmed/27746816 http://dx.doi.org/10.1155/2016/1872627 Text en Copyright © 2016 Chuang-Chi Liaw et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Liaw, Chuang-Chi Chang, Hung Liao, Tzu-Yao Wen, Ming-Sheng Yu, Chih-Teng Juan, Yu-Hsiang
spellingShingle	Liaw, Chuang-Chi Chang, Hung Liao, Tzu-Yao Wen, Ming-Sheng Yu, Chih-Teng Juan, Yu-Hsiang The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint
author_facet	Liaw, Chuang-Chi Chang, Hung Liao, Tzu-Yao Wen, Ming-Sheng Yu, Chih-Teng Juan, Yu-Hsiang
author_sort	Liaw, Chuang-Chi
title	The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint
title_short	The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint
title_full	The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint
title_fullStr	The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint
title_full_unstemmed	The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint
title_sort	role of pulmonary veins in cancer progression from a computed tomography viewpoint
description	Background. We studied the role of pulmonary veins in cancer progression using computed tomography (CT) scans. Methods. We obtained data from 260 patients with pulmonary vein obstruction syndrome (PVOS). We used CT scans to investigate pulmonary lesions in relation to pulmonary veins. We divided the lesions into central and peripheral lesions by their anatomical location: in the lung parenchymal tissue or pulmonary vein; in the superior or inferior pulmonary vein; and by unilateral or bilateral presence in the lungs. Results. Of the 260 PVOS patients, 226 (87%) had central lesions, 231 (89%) had peripheral lesions, and 190 (75%) had mixed central and peripheral lesions. Among the 226 central lesions, 93% had lesions within the superior pulmonary vein, either bilaterally or unilaterally. Among the 231 peripheral lesions, 65% involved bilateral lungs, 70% involved lesions within the inferior pulmonary veins, and 23% had obvious metastatic extensions into the left atrium. All patients exhibited nodules within their pulmonary veins. The predeath status included respiratory failure (40%) and loss of consciousness (60%). Conclusion. CT scans play an important role in following tumor progression within pulmonary veins. Besides respiratory distress, PVOS cancer cells entering centrally can result in cardiac and cerebral events and loss of consciousness or can metastasize peripherally from the pulmonary veins to the lungs.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055964/
_version_	1613677516263784448

The Role of Pulmonary Veins in Cancer Progression from a Computed Tomography Viewpoint

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