Biophysical Determinants for Cellular Uptake of Hydrocarbon-Stapled Peptide Helices

Hydrocarbon-stapled peptides are a class of bioactive alpha-helical ligands developed to dissect and target protein interactions. While there is consensus that stapled peptides can be effective chemical tools for investigating protein regulation, their broader utility for therapeutic modulation of i...

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Bibliographic Details
Main Authors: Bird, Gregory H., Mazzola, Emanuele, Opoku-Nsiah, Kwadwo, Lammert, Margaret A., Godes, Marina, Neuberg, Donna S., Walensky, Loren D.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055751/