Long-Lived CD4+IFN-γ+ T Cells rather than Short-Lived CD4+IFN-γ+IL-10+ T Cells Initiate Rapid IL-10 Production To Suppress Anamnestic T Cell Responses during Secondary Malaria Infection

Long-Lived CD4+IFN-γ+ T Cells rather than Short-Lived CD4+IFN-γ+IL-10+ T Cells Initiate Rapid IL-10 Production To Suppress Anamnestic T Cell Responses during Secondary Malaria Infection

CD4+ T cells that produce IFN-γ are the source of host-protective IL-10 during primary infection with a number of different pathogens, including Plasmodium spp. The fate of these CD4+IFN-γ+IL-10+ T cells following clearance of primary infection and their subsequent influence on the course of repeate...

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Bibliographic Details
Main Authors: Villegas-Mendez, Ana, Inkson, Colette A., Shaw, Tovah N., Strangward, Patrick, Couper, Kevin N.
Format: Online
Language:English
Published: AAI 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055201/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055201/

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