Integration of Known Transcription Factor Binding Site Information and Gene Expression Data to Advance from Co-Expression to Co-Regulation

The common approach to find co-regulated genes is to cluster genes based on gene expression. However, due to the limited information present in any dataset, genes in the same cluster might be co-expressed but not necessarily co-regulated. In this paper, we propose to integrate known transcription fa...

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Bibliographic Details
Main Authors: Clements, Maarten, van Someren, Eugene P., Knijnenburg, Theo A., Reinders, Marcel J.T.
Format: Online
Language:English
Published: Elsevier 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054099/