Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate

The MDM2 promoter region contains several polymorphisms, some of which have been associated with MDM2 expression, cancer risk and age at cancer onset. del1518 (rs3730485) is an indel polymorphism residing in the MDM2 promoter P1 and is in almost complete linkage disequilibrium with the MDM2 promoter...

Full description

Bibliographic Details
Main Authors:	Gansmo, Liv B., Vatten, Lars, Romundstad, Pål, Hveem, Kristian, Ryan, Bríd M., Harris, Curtis C., Knappskog, Stian, Lønning, Per E.
Format:	Online
Language:	English
Published:	Impact Journals LLC 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053751/

id	pubmed-5053751
recordtype	oai_dc
spelling	pubmed-50537512016-10-12 Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate Gansmo, Liv B. Vatten, Lars Romundstad, Pål Hveem, Kristian Ryan, Bríd M. Harris, Curtis C. Knappskog, Stian Lønning, Per E. Research Paper The MDM2 promoter region contains several polymorphisms, some of which have been associated with MDM2 expression, cancer risk and age at cancer onset. del1518 (rs3730485) is an indel polymorphism residing in the MDM2 promoter P1 and is in almost complete linkage disequilibrium with the MDM2 promoter P2 polymorphism SNP309T>G (rs2279744). Cancer risk assessments of del1518 have previously been conducted in relatively small Chinese populations only. In this study we assessed the genotype distribution of del1518 among healthy Caucasians, African Americans and Chinese, and we estimated the Odds Ratios (OR) for incident cancer of the breast, colon, lung and prostate (n=7,081) as compared to controls (n=3,749) in a large Caucasian (Norwegian) cohort. Impact Journals LLC 2016-04-12 /pmc/articles/PMC5053751/ /pubmed/27081698 http://dx.doi.org/10.18632/oncotarget.8705 Text en Copyright: © 2016 Gansmo et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Gansmo, Liv B. Vatten, Lars Romundstad, Pål Hveem, Kristian Ryan, Bríd M. Harris, Curtis C. Knappskog, Stian Lønning, Per E.
spellingShingle	Gansmo, Liv B. Vatten, Lars Romundstad, Pål Hveem, Kristian Ryan, Bríd M. Harris, Curtis C. Knappskog, Stian Lønning, Per E. Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate
author_facet	Gansmo, Liv B. Vatten, Lars Romundstad, Pål Hveem, Kristian Ryan, Bríd M. Harris, Curtis C. Knappskog, Stian Lønning, Per E.
author_sort	Gansmo, Liv B.
title	Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate
title_short	Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate
title_full	Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate
title_fullStr	Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate
title_full_unstemmed	Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate
title_sort	associations between the mdm2 promoter p1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate
description	The MDM2 promoter region contains several polymorphisms, some of which have been associated with MDM2 expression, cancer risk and age at cancer onset. del1518 (rs3730485) is an indel polymorphism residing in the MDM2 promoter P1 and is in almost complete linkage disequilibrium with the MDM2 promoter P2 polymorphism SNP309T>G (rs2279744). Cancer risk assessments of del1518 have previously been conducted in relatively small Chinese populations only. In this study we assessed the genotype distribution of del1518 among healthy Caucasians, African Americans and Chinese, and we estimated the Odds Ratios (OR) for incident cancer of the breast, colon, lung and prostate (n=7,081) as compared to controls (n=3,749) in a large Caucasian (Norwegian) cohort.
publisher	Impact Journals LLC
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053751/
_version_	1613675658699866112

Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate

Similar Items