Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis

Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes — A Meta-Analysis

•CHRNA5 rs16969968 confers risk for earlier lung cancer diagnosis, but quitting produces benefit regardless of genotype.•Smokers can cut their risk of lung cancer in half and delay its onset by 7 years among those diagnosed.•Precision prevention allows clinicians to provide personalized health benef...

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Bibliographic Details
Main Authors: Chen, Li-Shiun, Baker, Timothy, Hung, Rayjean J., Horton, Amy, Culverhouse, Robert, Hartz, Sarah, Saccone, Nancy, Cheng, Iona, Deng, Bo, Han, Younghun, Hansen, Helen M., Horsman, Janet, Kim, Claire, Rosenberger, Albert, Aben, Katja K., Andrew, Angeline S., Chang, Shen-Chih, Saum, Kai-Uwe, Dienemann, Hendrik, Hatsukami, Dorothy K., Johnson, Eric O., Pande, Mala, Wrensch, Margaret R., McLaughlin, John, Skaug, Vidar, van der Heijden, Erik H., Wampfler, Jason, Wenzlaff, Angela, Woll, Penella, Zienolddiny, Shanbeh, Bickeböller, Heike, Brenner, Hermann, Duell, Eric J., Haugen, Aage, Brüske, Irene, Kiemeney, Lambertus A., Lazarus, Philip, Le Marchand, Loic, Liu, Geoffrey, Mayordomo, Jose, Risch, Angela, Schwartz, Ann G., Teare, M. Dawn, Wu, Xifeng, Wiencke, John K., Yang, Ping, Zhang, Zuo-Feng, Spitz, Margaret R., Amos, Christopher I., Bierut, Laura J.
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049934/
Description
Summary:•CHRNA5 rs16969968 confers risk for earlier lung cancer diagnosis, but quitting produces benefit regardless of genotype.•Smokers can cut their risk of lung cancer in half and delay its onset by 7 years among those diagnosed.•Precision prevention allows clinicians to provide personalized health benefits of smoking cessation.

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