A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies

By whole exome sequencing, we recently identified a missense mutation (p.R703C) in the human ATP4a gene, which encodes the proton pump responsible for gastric acidification. This mutation causes an aggressive familial type I gastric neuroendocrine tumor in homozygous individuals. Affected individual...

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Bibliographic Details
Main Authors: Calvete, Oriol, Varro, Andrea, Pritchard, D. Mark, Barroso, Alicia, Oteo, Marta, Morcillo, Miguel Ángel, Vargiu, Pierfrancesco, Dodd, Steven, Garcia, Miriam, Reyes, José, Ortega, Sagrario, Benitez, Javier
Format: Online
Language:English
Published: The Company of Biologists Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047686/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047686/

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