Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation

Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation

Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a leading asexual blood stage vaccine candidate for malaria. In preparation for clinical trials, three Diversity Covering (DiCo) PfAMA1 ectodomain proteins, designed to overcome the intrinsic polymorphism that is present in PfAMA1, were pro...

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Bibliographic Details
Main Authors: Faber, Bart W., Hellwig, Stephan, Houard, Sophie, Havelange, Nicolas, Drossard, Jürgen, Mertens, Hubert, Croon, Alexander, Kastilan, Robin, Byrne, Richard, van der Werff, Nicole, van der Eijk, Marjolein, Thomas, Alan W., Kocken, Clemens H. M., Remarque, Edmond J.
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047445/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047445/

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