Coronary artery calcium is associated with cortical thinning in cognitively normal individuals

To evaluate the association between coronary artery calcium (CAC) and cortical thickness in a large sample of cognitively normal individuals, with special emphasis in determining if the association thickness has regional brain specificity and if it is mediated by white matter hyperintensities (WMH)....

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Main Authors:	Lee, Jin San, Kang, Danbee, Jang, Young Kyoung, Kim, Hee Jin, Na, Duk L., Shin, Hee Young, Kang, Mira, Yang, Jin-Ju, Lee, Jong-Min, Lee, Juyoun, Kim, Yeo Jin, Park, Key-Chung, Guallar, Eliseo, Seo, Sang Won, Cho, Juhee
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046153/

id	pubmed-5046153
recordtype	oai_dc
spelling	pubmed-50461532016-10-11 Coronary artery calcium is associated with cortical thinning in cognitively normal individuals Lee, Jin San Kang, Danbee Jang, Young Kyoung Kim, Hee Jin Na, Duk L. Shin, Hee Young Kang, Mira Yang, Jin-Ju Lee, Jong-Min Lee, Juyoun Kim, Yeo Jin Park, Key-Chung Guallar, Eliseo Seo, Sang Won Cho, Juhee Article To evaluate the association between coronary artery calcium (CAC) and cortical thickness in a large sample of cognitively normal individuals, with special emphasis in determining if the association thickness has regional brain specificity and if it is mediated by white matter hyperintensities (WMH). A total of 512 participants were included in this study. CAC scores were assessed by multi-detector computed tomography. Cortical thickness was measured using a surface-based method. Linear mixed models were used to assess the association between CAC scores and cortical thickness. In fully adjusted models, increased CAC scores were associated with cortical thinning across several brain regions, which generally overlapped with the distribution of default mode network. The association between CAC scores and cortical thickness was significantly stronger in participants with moderate or severe WMH compared to those with none or mild WMH, even though CAC scores were not associated with WMH. In cognitively normal adults, CAC was associated with cortical thinning in areas related to cognitive function. This association was evident after adjusting for multiple coronary artery disease risk factors and for WMH, suggesting that CAC may be more closely related to Alzheimer’s Disease-type disease rather than to cerebral small vessel disease. Nature Publishing Group 2016-10-03 /pmc/articles/PMC5046153/ /pubmed/27694965 http://dx.doi.org/10.1038/srep34722 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lee, Jin San Kang, Danbee Jang, Young Kyoung Kim, Hee Jin Na, Duk L. Shin, Hee Young Kang, Mira Yang, Jin-Ju Lee, Jong-Min Lee, Juyoun Kim, Yeo Jin Park, Key-Chung Guallar, Eliseo Seo, Sang Won Cho, Juhee
spellingShingle	Lee, Jin San Kang, Danbee Jang, Young Kyoung Kim, Hee Jin Na, Duk L. Shin, Hee Young Kang, Mira Yang, Jin-Ju Lee, Jong-Min Lee, Juyoun Kim, Yeo Jin Park, Key-Chung Guallar, Eliseo Seo, Sang Won Cho, Juhee Coronary artery calcium is associated with cortical thinning in cognitively normal individuals
author_facet	Lee, Jin San Kang, Danbee Jang, Young Kyoung Kim, Hee Jin Na, Duk L. Shin, Hee Young Kang, Mira Yang, Jin-Ju Lee, Jong-Min Lee, Juyoun Kim, Yeo Jin Park, Key-Chung Guallar, Eliseo Seo, Sang Won Cho, Juhee
author_sort	Lee, Jin San
title	Coronary artery calcium is associated with cortical thinning in cognitively normal individuals
title_short	Coronary artery calcium is associated with cortical thinning in cognitively normal individuals
title_full	Coronary artery calcium is associated with cortical thinning in cognitively normal individuals
title_fullStr	Coronary artery calcium is associated with cortical thinning in cognitively normal individuals
title_full_unstemmed	Coronary artery calcium is associated with cortical thinning in cognitively normal individuals
title_sort	coronary artery calcium is associated with cortical thinning in cognitively normal individuals
description	To evaluate the association between coronary artery calcium (CAC) and cortical thickness in a large sample of cognitively normal individuals, with special emphasis in determining if the association thickness has regional brain specificity and if it is mediated by white matter hyperintensities (WMH). A total of 512 participants were included in this study. CAC scores were assessed by multi-detector computed tomography. Cortical thickness was measured using a surface-based method. Linear mixed models were used to assess the association between CAC scores and cortical thickness. In fully adjusted models, increased CAC scores were associated with cortical thinning across several brain regions, which generally overlapped with the distribution of default mode network. The association between CAC scores and cortical thickness was significantly stronger in participants with moderate or severe WMH compared to those with none or mild WMH, even though CAC scores were not associated with WMH. In cognitively normal adults, CAC was associated with cortical thinning in areas related to cognitive function. This association was evident after adjusting for multiple coronary artery disease risk factors and for WMH, suggesting that CAC may be more closely related to Alzheimer’s Disease-type disease rather than to cerebral small vessel disease.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046153/
_version_	1613669367504961536

Coronary artery calcium is associated with cortical thinning in cognitively normal individuals

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