Glycine triggers a non-ionotropic activity of GluN2A-containing NMDA receptors to confer neuroprotection

Glycine triggers a non-ionotropic activity of GluN2A-containing NMDA receptors to confer neuroprotection

Ionotropic activation of NMDA receptors (NMDARs) requires agonist glutamate and co-agonist glycine. Here we show that glycine enhances the activation of cell survival-promoting kinase Akt in cultured cortical neurons in which both the channel activity of NMDARs and the glycine receptors are pre-inhi...

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Bibliographic Details
Main Authors: Hu, Rong, Chen, Juan, Lujan, Brendan, Lei, Ruixue, Zhang, Mi, Wang, Zefen, Liao, Mingxia, Li, Zhiqiang, Wan, Yu, Liu, Fang, Feng, Hua, Wan, Qi
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046082/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046082/

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